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KMID : 0605720120180020238
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Journal of the Korean Society of Biological Therapies in Psychiatry
2012 Volume.18 No. 2 p.238 ~ p.245
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The Association between Smoking and Prolonged QT Intervals in Schizophrenic Patients
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Park Min-Kyung
Shim Joo-Cheol
Kong Bo-Geum
Kang Je-Wook
Moon Jung-Joon
Shin Hye-Kyung
Kim Hyun-Jung
Kim Jung-Min
Oh Min-Kyung
Jung Do-Un
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Abstract
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Objectives: Abnormalities in the QT interval have been associated with an increased risk of ventricular arrhythmias and sudden cardiac death. However, there is no clear correlation between cigarette smoking and QT interval prolongation in schizophrenia. The purpose of this study is to evaluate the effects of cigarette smoking on the QT interval and estimate the prevalence of prolonged QT interval in schizophrenic patients who take antipsychotics.
Methods: We studied 106 schizophrenic patients taking antipsychotics and age- and sex-matched 106 people in control group. A prolonged QTc interval was defined as ＞450 msec in men and ＞470 msec in women. The demographic data and clinical characteristics of subjects were collected from medical records. The correlations between QTc interval and other variables were assessed using a regression analysis.
Results: There was no significant association between cigarette smoking and QT interval. The mean QT interval was not significantly influenced by antipsychotic dose and type of antipsychotics. However, there was significantly prolonged QT interval in schizophrenic patients(421.1±25.7 msec) compared to control group(412.1±17.1 msec) (p=0.003). The prevalence of prolonged QT interval in schizophrenic patients was 6.6%(7 of 106 patients). Five patients( 71.4%) were smoker and six patients(85.7%) had obesity. By contrast, nobody had a prolonged QT interval in control group.
Conclusions: The prevalence of prolonged QT interval was relatively high among middle aged schizophrenia patients. And there was significantly prolonged QT interval and higher body mass index in schizophrenia patients.
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KEYWORD
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Schizophrenia, Antipsychotics, QT prolongation, Smoking
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